Neokyotorphin and neokyotorphin (1–4): secretion by erythrocytes and regulation of tumor cell growth
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- 作者：Blishchenko ; Elena Yu. ; Mernenko ; Olga A. ; Yatskin ; Oleg N. ; Ziganshin ; Rustam H. ; Philippova ; Marina M. ; et. al.
- 关键词：Neokyotorphin ; Erythrocytes primary culture ; Tumor cell ; Proliferation
- 刊名：FEBS Letters
- 出版年：1997
- 出版时间：September 1, 1997
- 年：1997
- 卷：414
- 期：1
- 页码：125-128
- 全文大小：298 K
文摘
Human erythrocytes release neokyotorphin, the 137–141 fragment of hemoglobin α-chain into the supernatant of red blood cells primary culture. However, the neokyotorphin fragment 1–4 that is formed together with neokyotorphin inside the red blood cells and in various tissues is not found in the supernatant. Both neokyotorphin and its 1–4 fragment were shown to stimulate proliferation of L929 tumor cells.