Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15R-Lipoxin A₄

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• 作者：Phillips ; Eifion D. ; Chang ; Hui-Fang ; Holmquist ; Christopher R. ; McCauley ; John P.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2003
• 出版时间：October 16, 2003
• 年：2003
• 卷：13
• 期：19
• 页码：3223-3226
• 全文大小：155 K

文摘

We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A₄.