Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating

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• 作者：Hong Ren^a ; ^{hongren169@163.com} ; Yulin Zhao^b ; ^{yulin.zhao@yahoo.com} ; Man Wu^c ; ^{maw246@pitt.edu} ; Donard S. Dwyer^d ; ^{DDwyer@lsuhsc.edu} ; Robert W. Peoples^e ; ^{robert.peoples@marquette.edu}
• 关键词：Glutamate ; Ion channel ; Ethanol
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：20-33
• 全文大小：2351 K
• 卷排序：114

文摘

Two phenylalanine residues in the NMDA receptor GluN2A subunit M3 domain influence alcohol action and ion channel gating. Mutations at these positions interactively affect alcohol sensitivity and receptor function. A mutation at one position can reverse the effect of a similar mutation at the other position. These effects may arise from hydrophobic and aromatic interactions with surrounding side chains.