Regulation of cell migration and inflammation by ceramide 1-phosphate
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- 作者：Natalia Presaa ; Ana Gomez-Larraurib ; Io-Guané ; Riveraa ; Marta Ordoñ ; eza ; Miguel Truebaa ; Antonio Gomez-Muñ ; oza ; antonio.gomez@ehu.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; arachidonic acid ; Akt (PKB) ; protein kinase ; BMDM ; bone marrow-derived macrophages ; CerK ; ceramide kinase ; C1P ; ceramide 1-phosphate ; cPLA2 ; calcium-dependent cytosolic phospholipase 2 ; ERK ; extracellularly regulated kinases ; GLUT ; glucose transporter ; MCP-1 ; monocyte chemoattractant protein-1 ; iNOS ; inducible nitric oxide synthase ; PA ; phosphatidic acid ; PI3K ; phosphatidylinositol 3-kinase ; PKC ; protein kinase C ; PTX ; pertussis toxin ; ROS ; reactive oxygen species ; SMase ; sphingomyelinase ; S
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：1861
- 期：5
- 页码：402-409
- 全文大小：881 K
文摘
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Ceramide 1-phosphate (C1P) is mitogenic and antiapoptotic.
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10">C1P promotes cell migration and invasion.
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15">C1P can be pro- or anti-inflammatory depending on cell type.