Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study

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• 作者：Katsunori Shijo^a ; ¹ ; ^{sijyou.katsunori@nihon-u.ac.jp} ; Richard L. Sutton^a ; ^{rsutton@ucla.edu} ; Sima S. Ghavim^a ; ^{sghavim@mednet.ucla.edu} ; Neil G. Harris^a ; ^{ngharris@ucla.edu} ; Brenda L. Bartnik-Olson^b ; ^{bbartnik@llu.edu}
• 关键词：Controlled cortical impact ; Ethyl pyruvate ; Glucose ; Oxidative metabolism ; Pentose phosphate pathway ; Sodium pyruvate
• 刊名：Neurochemistry International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：66-78
• 全文大小：1051 K
• 卷排序：102

文摘

Metabolism following brain injury and treatment with exogenous fuels was studied. Injury-induced increases in lactate labeling via the pentose phosphate and pyruvate recycling pathways were not improved by fuel treatment. Sodium pyruvate improved neuronal oxidative metabolism. Injury-induced decreases in labeling via pyruvate carboxylase were improved by fuel treatment. Metabolic effects in astrocytes may contribute to improved cerebral glucose utilization following injury.