Astrocyte arachidonate and palmitate uptake and metabolism is differentially modulated by dibutyryl-cAMP treatment
详细信息 查看全文
- 作者：D.R. Seegera ; C.C. Murphyb ; E.J. Murphya ; eric.murphy@med.und.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：TAG ; triacylglycerol(s) ; FFA ; free fatty acids ; DAG ; diacylglycerol(s) ; EtnGpl ; ethanolamine glycerophospholipids ; PtsIns ; phosphatidylinositol ; PtdSer ; phosphatidylserine ; ChoGpl ; choline glycerophospholipids ; CerPCho ; sphingomyelin ; 16 ; 0 ; palmitic acid ; 18 ; 2n-6 ; linoleic acid ; 20 ; 4n-6 ; arachidonic acid ; 22 ; 6n-3 ; docosahexaenoic acid ; ApoE ; apolipoprotein E ; dBcAMP ; dibutyryl-cAMP ; Acsl ; long-chain acyl-CoA synthetase ; LDLR ; low-density lipoprotein receptors ; PUFA ; polyunsaturated fatty acids
- 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：110
- 期：Complete
- 页码：16-26
- 全文大小：794 K
文摘
- •
dBcAMP treatment increases arachidonate uptake into astrocytes.
- •
dBcAMP treatment increases arachidonate and palmitate targeting into phospholipids in astrocytes.
- •
dBcAMP treatment increases gene expression of Acsl3 and 4 in astrocytes.
- •
dBcAMP treatment reduces gene expression of Acot7 in astrocytes.