Oxidative stress leads to reduction of plasmalogen serving as a novel biomarker for systemic lupus erythematosus

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• 作者：Changfeng Hu^a ; ¹ ; Jia Zhou^a ; ¹ ; Shasha Yang^a ; Haichang Li^a ; Chunyan Wang^b ; Xiaoling Fang^b ; Yongsheng Fan^a ; Jida Zhang^a ; Xianlin Han^a ; ^b ; ^{xhan@sbpdiscovery.org} ; Chengping Wen^a ; ^{cpwen.zcmu@yahoo.com}
• 关键词：CVD ; cardiovascular disease ; FA ; fatty acyl ; Fmoc ; fluorenylmethoxycarbonyl ; HDL ; high-density lipoprotein ; HNE ; 4-hydroxy-2(E)-nonenal ; ox-LDL ; oxidized low-density lipoprotein ; MDMS-SL ; multi-dimensional mass spectrometry-based shotgun lipidomics ; PC ; choline glycerophospholipid ; aPC ; plasmanylcholine ; dPC ; phosphatidylcholine ; pPC ; plasmenylcholine ; LPC ; lysoPC ; PE ; ethanolamine glycerophospholipid ; aPE ; plasmanylethanolamine ; dPE ; phosphatidylethanolamine ; pPE ; ethanolamine plasmalogen ; LPE
• 刊名：Free Radical Biology and Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：475-481
• 全文大小：804 K
• 卷排序：101

文摘

Tight relationships among oxidative stress, aberrant lipid metabolism, and proinflammtory cytokines in systemic lupus erythmatosus (SLE). Shotgun lipidomics technology for quantitatively analyzing a panel of oxidation-related lipids in sera of SLE patients. Oxidation-related lipids might be novel biomarkers for diagnosis of SLE.