Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein
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- 作者：Peter Y. Mercredi1 ; Nadine Bucca1 ; Burk Loeliger1 ; Christy R. Gaines1 ; Mansi Mehta1 ; Pallavi Bhargava1 ; Philip R. Tedbury2 ; Landry Charlier3 ; Nicolas Floquet3 ; Delphine Muriaux4 ; Cyril Favard4 ; Charles R. Sanders5 ; Eric O. Freed2 ; efreed@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Jan Marchant1 ; janm@umbc.edu" class="auth_mail" title="E-mail the corresponding author ; Michael F. Summers1 ; summers@hhmi.umbc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PM ; plasma membrane ; MA ; myristoylated matrix ; PI(4 ; 5)P2 ; phosphatidylinositol-4 ; 5-bisphosphate ; HIV ; human immunodeficiency virus ; HBR ; highly basic region ; PIPs ; phosphoinositidyl phosphates ; PS ; phosphatidylserine ; pl-PE ; plasmalogen-phosphatidylethanolamine ; CG ; coarse-grained ; CA ; capsid ; NC ; nucleocapsid ; DHPC ; 1 ; 2-dihexanoyl-sn-glycero-3-phosphocholine ; PC ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine ; PI(3 ; 5)P2 ; phosphatidylinositol-3 ; 5-bisphosphate ; PI(4)P ; phosphatidylinositol-4-ph
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：24 April 2016
- 年：2016
- 卷：428
- 期：8
- 页码：1637-1655
- 全文大小：2085 K
文摘
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The influences of lipid constituents on membrane binding by HIV-1 MA were determined.
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NMR results differed from those obtained by non-equilibrium flotation assays.
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The structural basis for PI(4,5)P2-dependent membrane targeting was re-examined.
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Native PI(4,5)P2 does not bind MA in a predicted “extended lipid” conformation.
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MA may bind non-raft regions and recruit raft-like constituents during assembly.