FTIR spectral signature of anticancer drugs. Can drug mode of action be identified?
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- 作者：Alix Mignoleta ; Allison Derennea ; Margarita Smolinaa ; Bayden R. Woodb ; Erik Goormaghtigha ; egoor@ulb.ac.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：IR ; Infrared ; FTIR ; Fourier Transform Infrared ; h ; hours ; PC ; phosphatidylcholine ; PE ; phosphatidylethanolamine ; PS ; phosphatidylserine ; PI ; phosphatidylinositol ; SM ; sphingomyelin ; CL ; cardiolipin ; CH ; cholesterol ; DOPE ; 1 ; 2-dioleoyl-sn-glycero-3-phosphoethanolamine ; HPLC ; high performance liquid chromatography ; TLC ; thin layer chromatography ; PLS ; partial least square
- 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1864
- 期：1
- 页码：85-101
- 全文大小：1962 K
文摘
- 20">
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315">We review the potential of infrared spectroscopy of cancer cells to reveal anticancer drug modes of action
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320">Infrared spectroscopy is a label free sensor for nucleic acids, proteins, lipids, glycosylations, phosphorylations etc.
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325">We suggest IR spectroscopy could be used to classify new potential drug molecules