Cell death mechanistic study of photodynamic therapy against breast cancer cells utilizing liposomal delivery of 5,10,15,20-tetrakis(benzo[b]thiophene) porphyrin

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• 作者：Geewoo Nam ; Sabarinathan Rangasamy ; Hee Ju ; Annie Agnes Suganya Samson ; Joon Myong Song ; ^{jmsong@snu.ac.kr}
• 关键词：BTP ; 5 ; 10 ; 15 ; 20-tetrakis(benzo[b]thiophene) porphyrin ; DOPC ; 1 ; 2-dioleoyl-sn-glycero-3-phosphocholine ; DOPE ; 1 ; 2-dioleoyl-sn-glycero-3-phosphoethanolamine ; DPPC ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphocholine ; PS ; phosphatidylserine ; PI ; phosphatidylinositol ; TPPS ; 4 ; 4&prime ; 4&Prime ; 4‴-(porphine-5 ; 10 ; 15 ; 20-tetrayl)tetrakis(benzenesulfonic acid)
• 刊名：Journal of Photochemistry and Photobiology B: Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：116-125
• 全文大小：1509 K
• 卷排序：166

文摘

Hydrophobic BTP induced photodynamic effects against MCF-7 breast cancer cells. The lipid composition of the liposomes affected the subcellular localization of BTP. DOPC-BTP and DOPE-BTP were localized in the nucleus. M1-BTP and M2-BTP were localized mainly in the ER and partially in the nucleus. The cancer cell death mechanism depended on the subcellular localization.