Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate

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• 作者：Antonio Gomez-Muñ ; oz^a ; ^{antonio.gomez@ehu.es" class="auth_mail" title="E-mail the corresponding author} ; Natalia Presa^a ; ^{npretor@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ana Gomez-Larrauri^b ; ^{ana.gomezlarrauri@osakidetza.net" class="auth_mail" title="E-mail the corresponding author} ; Io-Guané ; Rivera^a ; ^{io_rivera@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Miguel Trueba^a ; ^{miguel.trueba@ehu.es" class="auth_mail" title="E-mail the corresponding author} ; Marta Ordoñ ; ez^a ; ^{marta.ordonez87@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Akt (PKB) ; protein kinase ; CerK ; ceramide kinase ; C1P ; ceramide 1-phosphate ; cPLA2 ; calcium-dependent cytosolic phospholipase 2 ; ERK ; extracellularly regulated kinases ; iNOS ; inducible nitric oxide synthase ; PKC ; protein kinase C ; PI3K ; phosphatidylinositol 3-kinase ; ROS ; reactive oxygen species ; SMase ; sphingomyelinase ; SPT ; serine palmitoyl transferase
• 刊名：Progress in Lipid Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：61
• 期：Complete
• 页码：51-62
• 全文大小：1044 K

文摘

Inflammation is a network of complex processes involving a variety of metabolic and signaling pathways aiming at healing and repairing damage tissue, or fighting infection. However, inflammation can be detrimental when it becomes out of control. Inflammatory mediators involve cytokines, bioactive lipids and lipid-derived metabolites. In particular, the simple sphingolipids ceramides, sphingosine 1-phosphate, and ceramide 1-phosphate have been widely implicated in inflammation. However, although ceramide 1-phosphate was first described as pro-inflammatory, recent studies show that it has anti-inflammatory properties when produced in specific cell types or tissues. The biological functions of ceramides and sphingosine 1-phosphate have been extensively studied. These sphingolipids have opposing effects with ceramides being potent inducers of cell cycle arrest and apoptosis, and sphingosine 1-phosphate promoting cell growth and survival. However, the biological actions of ceramide 1-phosphate have only been partially described. Ceramide 1-phosphate is mitogenic and anti-apoptotic, and more recently, it has been demonstrated to be key regulator of cell migration. Both sphingosine 1-phosphate and ceramide 1-phosphate are also implicated in tumor growth and dissemination. The present review highlights new aspects on the control of inflammation and cell migration by simple sphingolipids, with special emphasis to the role played by ceramide 1-phosphate in controlling these actions.