Melanoma antigen-D2: A nucleolar protein undergoing delocalization during cell cycle and after cellular stress
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- 作者：Cé ; line Pirlota ; Marc Thiryb ; Charlotte Trussarta ; Emmanuel Di Valentinc ; Jacques Piettea ; Yvette Habrakena ; yvette.habraken@ulg.ac.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：CPT ; Camptothecin ; CTA ; Cancer/testis antigen ; DFC ; Dense fibrillar component ; DRB ; 5 ; 6-dichloro-1-beta-D-ribofuranosylbenzimidazole ; eGFP ; Enhanced green fluorescent protein ; FBL ; Fibrillarin ; FC ; Fibrillar center ; GC ; Granular component ; MAGE ; Melanoma antigen ; MHD ; MAGE homology domain ; NLS ; Nuclear localization signal ; NoLS ; Nucleolar localization signal ; NPM ; Nucleophosmin ; UBF ; Upstream binding factor ; PIKK ; Phosphatidylinositol 3-kinase (PI3K)-related kinases
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1863
- 期：4
- 页码：581-595
- 全文大小：3560 K
文摘
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MAGE-D2 is a cytoplasmic and nucleoplasmic protein that accumulates in the nucleoli.
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MAGE-D2 is a highly mobile nucleolar protein which interacts with nucleolin.
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MAGE-D2 localization varies during cell cycle in a different manner than nucleolin.
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The arginine-rich domain of MAGE-D2 encompasses several NLS and NoLS.
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After nucleolar stress, MAGE-D2 accumulation in the nucleoplasm is p-ERK dependent.