Natural products for treatment of bone erosive diseases: The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption
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- 作者：Jing An ; Dingjun Hao ; Qian Zhang ; Bo Chen ; Rui Zhang ; Yi Wang ; Hao Yang ; yanghao.71_99@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MNCs ; multinucleated cells ; TRAP ; tartrate-resistant acid phosphatase ; RANKL ; receptor activator of nuclear factor-κB ligand ; M-CSF ; macrophage colony stimulating factor ; OPG ; osteoprotegerin ; c-fms ; colony-stimulating factor-1 receptor ; ERK ; extracellular signal regulated protein kinases ; PI3K ; phosphatidylinositol 3-kinase ; Akt ; protein kinase B ; TNF ; tumor necrosis factor ; TRAF6 ; TNF receptor-associated factor 6 ; NF-κB ; nuclear factor-κB ; MAPKs ; mitogen activated protein kinases ; JNK ; c-jun-N
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：118-131
- 全文大小：818 K
文摘
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Excessive bone resorption plays a central role on the bone erosive diseases.
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Osteoclasts are multinuclear giant cells responsible for bone resorption.
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Osteoclastogenesis is regulated by many factors, cytokines, and signaling pathways.
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Many plant-derived natural compounds inhibit osteoclast differentiation and function.
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Natural compounds regulate RANKL-related downstream signaling pathways.