Recent topics in catalytic asymmetric hydrogenation of ketones

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• 作者：Masahiro Yoshimura^a ; ^{yoshim@dpc.agu.ac.jp" class="auth_mail} ; Shinji Tanaka^b ; ^{tanaka@os.rcms.nagoya-u.ac.jp" class="auth_mail} ; Masato Kitamura^b ; ^{kitamura@os.rcms.nagoya-u.ac.jp" class="auth_mail}
• 关键词：Homogeneous catalysis ; Asymmetric hydrogenation ; Ketones ; Ligand design
• 刊名：Tetrahedron Letters
• 出版年：2 July 2014
• 年：2014
• 卷：55
• 期：27
• 页码：3635-3640
• 全文大小：2188 K

文摘

Asymmetric hydrogenation of ketones (AHK) was revolutionized in 1987 and again in 1995 when Ru(CH₃COO)₂(binap)/HCl and RuCl₂(binap)/diamine, respectively, were developed. Since then, the number of reports on Ru-catalyzed AHK has increased exponentially, and the utility of other precious metals (Os, Rh, Ir, and Pd) has also been shown. The utilization of inexpensive base metals (Fe, Co, Ni, and Cu) has been a recent trend. This digest summarizes the key advances in AHK in the past decade by categorizing the chiral ligands into six types: (i) diphosphines, (ii) diphosphines/diamines, (iii) tridentate or tetradentate phosphine amines, (iv) diamines, (v) tetradentate amines, and (vi) tetradentate thioether amines.