Blockade of metabotropic glutamate receptor 5 protects against DNA damage in a rotenone-induced Parkinson's disease model
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- 作者：Ning Xiaa ; Qian Zhanga ; Shu Ting Wanga ; Li Gua ; Hui Min Yanga ; Li Liua ; Rachit Bakshib ; Hui Yanga ; Hong Zhanga ; hzhang@ccmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：DHPG ; (s)-3 ; 5- dihydroxy-phenylglycine ; DMSO ; dimethylsulfoxide ; ERK ; extracellular signal-regulated kinase ; MAPK ; mitogen-activated protein kinase ; mGluR5 ; metabotropic glutamate receptor 5 ; MPEP ; 2-methyl-6-(phenylethynyl)pyridine ; PD ; Parkinson&rsquo ; s disease ; ROS ; reactive oxygen species ; TH ; tyrosine hydroxylase ; [Ca2+]i ; intracellular calcium ; ER ; endoplasmic reticulum ; γ-H2AX ; phospho-histone H2AX ; MMP ; mitochondrial membrane potential ; 8-OHdG ; 8-hydroxy-2&lsquo ; -deoxyguanosine ; BAPTA ; 1
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：567-580
- 全文大小：5936 K
文摘
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Inhibition of mGluR5 alleviates rotenone-induced DNA damage in MN9D dopaminergic cells.
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Inhibition of mGluR5 alleviates DNA damage by decreasing rotenone-induced [Ca2+]i ER-release and protecting against reactive oxygen species (ROS)-related mitochondria dysfunction.
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DNA repair plays a role in mGluR5 inhibition-mediated protection against DNA damage.
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mGluR5-mediated neuroprotection in a rat model of PD.