Heterogeneity of the serine synthetic pathway in Entamoeba species
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- 作者：Yoko Chibaa ; b ; 1 ; Takashi Makiuchib ; 2 ; Ghulam Jeelanib ; Tomoyoshi Nozakia ; b ; nozaki@nih.go.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CS ; cysteine synthase ; PGDH ; phosphoglycerate dehydrogenase ; PSAT ; 3-phosphoserine aminotransferase ; PSP ; phosphoserine phosphatase ; dPSP ; Mg2+-dependent PSP ; iPSP ; metal-independent PSP
- 刊名：Molecular & Biochemical Parasitology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：207
- 期：2
- 页码：56-60
- 全文大小：716 K
文摘
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Phosphoserine phosphatase (PSP) is the final enzyme in serine biosynthesis.
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PSP has been identified and characterized in a protozoan parasite of reptiles, Entamoeba invadens.
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E. invadens likely gained PSP gene by lateral gene transfer.
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Primate Entamoeba species including E. histolytica apparently lack PSP.
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Heterogeneity in the serine biosynthetic pathway exists in the genus Entamoeba.