Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking

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• 作者：Carlo Cosimo Campa ; Emilio Hirsch ; ^{emilio.hirsch@unito.it}
• 刊名：Advances in Biological Regulation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：63
• 期：Complete
• 页码：132-139
• 全文大小：643 K
• 卷排序：63

文摘

Rab11 and phosphoinositides are signal transducers able to direct the delivery of membrane components to the cell surface. Rab11 is a small GTPase that, by cycling from an active to an inactive state, controls key events of vesicular transport, while phosphoinositides are major determinants of membrane identity, modulating compartmentalized small GTPase function. By sharing common effectors, these two signal transducers synergistically direct vesicular traffic to specific intracellular membranes. This review focuses on the latest advances regarding the mechanisms that ensure the compartmentalized regulation of Rab11 function through its interaction with phosphoinositides.