Divergent functional profiles of acidic and basic phospholipases A2 in the venom of the snake Porthidium lansbergii lansbergii
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- 作者：Elié ; cer Jimé ; nez-Charrisa ; Leonel Montealegre-Sá ; ncheza ; Luis Solano-Redondob ; Fernando Castro-Herrerab ; Leonardo Fierro-Pé ; rezc ; Bruno Lomonted ; bruno.lomonte@ucr.ac.cr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Snake venom ; Porthidium lansbergii lansbergii ; Phospholipase A2 ; Myotoxin ; Cytotoxin
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：289-298
- 全文大小：2416 K
文摘
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Two novel phospholipases A2 were isolated from Porthidium l. lansbergii venom.
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They belong to the acidic and basic Asp49-PLA2 groups, respectively.
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They a markedly different profile of activities.
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Toxicity is associated with the basic enzyme but not the acidic one.