Mitochondrial contact sites as platforms for phospholipid exchange

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• 作者：Kai Stefan Dimmer ; ^{kai-stefan.dimmer@uni-tuebingen.de} ; Doron Rapaport
• 关键词：ERMES complex ; vCLAMP ; Mitochondria ; Phospholipids ; Contact sites
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1862
• 期：1
• 页码：69-80
• 全文大小：1095 K
• 卷排序：1862

文摘

Homeostasis of mitochondrial phospholipids depends on membrane contact sites. ERMES complex is the first system shown to be involved in mitochondrial glycerophospholipid exchange with other organelles. ERMES subunits actively bind lipid molecules for transport. ERMES-independent pathways contribute to exchange of lipids between mitochondria and other cellular compartments.