Catalytic synthesis of α-amino chromone phosphonates and their antimicrobial, toxicity and potential HIV-1 RT inhibitors based on silico screening

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• 作者：Abosede Oluwabukola Jaiyeola^a ; K. Anand^a ; ^b ; ^{organicanand@gmail.com} ; K. Kasumbwe^c ; M. Ramesh^d ; R.M. Gengan^a ; ^{genganrm@dut.ac.za}
• 关键词：Boron nitride ; Kabachnik-Fields reaction ; Molecular docking ; Antimicrobial ; HIV-1 reverse transcriptase
• 刊名：Journal of Photochemistry and Photobiology B: Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：136-147
• 全文大小：2678 K
• 卷排序：166

文摘

Novel α-amino chromone phosphonates ACPs were synthesized via one-pot reaction. All compounds were characterized by FTIR, NMR (1H, 13C, 31P, 2D NMR), HRMS. Catalyst was characterized by SEM-EDX, XRD, BET, DSC-TGA and Raman. Synthesized ACPs were evaluated for antimicrobial activity and toxicity. ACPs were found to be a potential candidate for the inhibition of HIV-1 RT.