Post-translational modification of polyketide and nonribosomal peptide synthases
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- 作者：Walsh ; Christopher T ; Gehring ; Amy M ; Weinreb ; Paul H ; Quadri ; Luis EN ; Flugel ; Roger S
- 关键词：ACP acyl carrier protein ; ACPS acyl carrier protein synthase ; ArCP aryl carrier protein ; DEBS deoxyerythronolide B synthase ; PCP peptidyl carrier protein ; PKS polyketide synthase ; P-pant 4'phosphopantetheine ; PPTase phosphopantetheinyl transferase
- 刊名：Current Opinion in Chemical Biology
- 出版年：1997
- 出版时间：October, 1997
- 年：1997
- 卷：1
- 期：3
- 页码：309-315
- 全文大小：719 K
文摘
The past year has witnessed a major advance in the study of polyketide and nonribosomal peptide biosynthesis with the identification of the phosphopantetheinyl transferase enzyme family, enzymes required to produce active, post-translationally modified polyketide and peptide synthases. Phosphopantetheinyl transferases required for fatty acid, peptide and siderophore biosynthesis have been characterized and a consensus sequence noted in order to facilitate future identification of additional proteins catalyzing phosphopantetheinyl transfer.