The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175WT/HD mice
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- 作者：A.B. Wehnera ; b ; A.M. Milena ; R.L. Albinb ; c ; B.A. Pierchalaa ; b ; pierchal@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bcl-XL ; B-cell lymphoma-extra large ; BDNF ; brain-derived neurotrophic factor ; DARPP-32 ; dopamine and cAMP-regulated phosphoprotein ; MW 32 ; kDa ; HD ; Huntington&rsquo ; s disease ; HTT ; Huntingtin protein ; IHC ; immunohistochemistry ; JNK ; c-Jun N-terminal kinase ; mHTT ; mutated HTT ; MSN ; medium spiny neuron ; NFκB ; nuclear factor kappa B ; p75 ; p75 neurotrophin receptor ; PBS ; phosphate-buffered saline ; PFA ; paraformaldehyde ; PTEN ; phosphatase and tensin homolog ; RE1/NRSE ; repressor element 1/neuron-r
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：324
- 期：Complete
- 页码：297-306
- 全文大小：1331 K
文摘
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Increased survival signaling in pre-symptomatic Q175 mice abolished by p75 deletion.
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Q175WT/HD;p75−/− mice have decreased expression of XIAP, Bcl-XL, and DARPP-32.
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Q175WT/HD;p75−/− mice have a more advanced decrease in striatal volume.