Investigating the effects of in utero benzene exposure on epigenetic modifications in maternal and fetal CD-1 mice
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- 作者：Nicola A. Philbrooka ; Louise M. Winna ; b ; winnl@queensu.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：纬H2AX ; phosphorylated histone H2A variant X ; TSA ; trichostatin A ; Parp-1 ; poly[ADP-ribose] synthase 1 ; HAT ; histone acetyltransferase ; Pten ; phosphatase and tensin homolog ; MAGE1 ; melanoma antigen 1 ; HDAC ; histone deacetylase ; DNMT ; DNA methyl transferase ; ROS ; reactive oxygen species ; GD ; gestational day ; CDKN2B ; cyclin-dependent kinase 4 inhibitor 2B ; MTS2 ; tumor suppressor gene 2 ; CDK ; cyclin dependent kinase ; PhIP ; 2-amino-1-methyl-6-phenylimidazo[4 ; 5b]pyridine ; ABP ; 4-aminobiphenyl
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：289
- 期：1
- 页码：12-19
- 全文大小：795 K
文摘
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Benzene exposure in pregnant mice decreased global DNA methylation in maternal bone marrow.
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Benzene exposure in pregnant mice had no effect on global DNA methylation in fetal livers.
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No effect of benzene exposure was observed on p15 promoter methylation.
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No effect of benzene on measured histone modifications in both maternal bone marrow and fetal livers was observed.