UPRmt-mediated cytoprotection and organismal aging
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- 作者：Anna M. Schulza ; schulza@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Cole M. Haynesa ; b ; haynesc@mskcc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：UPRmt ; mitochondrial unfolded protein response ; ATFS-1 ; activating transcription factor associated with stress-1 ; mtDNA ; mitochondrial DNA ; OxPhos ; oxidative phosphorylation ; TCA cycle ; tricarboxylic acid cycle ; ATP ; adenosine triphosphate ; Hsp ; heat shock protein ; TIM ; translocase of the inner membrane ; TOM ; translocase of the outer membrane ; MTS ; mitochondrial targeting sequence ; NLS ; nuclear localization sequence ; Tor ; target of rapamycin ; uORF ; upstream open reading frame ; ROS ; reactive oxyg
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：1847
- 期：11
- 页码：1448-1456
- 全文大小：540 K
文摘
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Mitochondrial dysfunction activates a transcriptional response known as the UPRmt.
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UPRmt activation is regulated by mitochondrial protein import efficiency of ATFS-1.
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The ATFS-1-mediated UPRmt includes mitochondrial proteostasis and innate immune genes.
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The UPRmt also includes a metabolic shift towards glycolysis.
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Modest mitochondrial dysfunction activates the UPRmt and confers longevity.