Nitric oxide-mediated resistance to photodynamic therapy in a human breast tumor xenograft model: Improved outcome with NOS2 inhibitors

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• 作者：Jonathan M. Fahey ; Albert W. Girotti ; ^{agirotti@mcw.edu}
• 关键词：Nitric oxide ; Photodynamic therapy ; Breast cancer ; Human tumor xenograft model
• 刊名：Nitric Oxide
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：62
• 期：Complete
• 页码：52-61
• 全文大小：1212 K
• 卷排序：62

文摘

Human breast cancer MDA-MB-231 cells in vitro overexpress iNOS after a 5-aminolevulinic acid (ALA)-photodynamic therapy (PDT)-like challenge. iNOS-derived NO acts cytoprotectively and stimulates surviving cell growth and invasion. ALA-PDT activates/upregulates pro-survival/progression effector proteins in vitro. ALA-PDT suppresses SCID mouse-borne MDA-MB-231 tumor xenografts and iNOS inhibition enhances this suppression. ALA-PDT upregulates iNOS protein and NO-derived nitrite in MDA-MB-231 tumors.