Cell adhesion on surface patterns generated by the photocrosslinking of hyperbranched polyesters with a trisdiazonium salt

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• 作者：Miguel Lomba^a ; Luis Oriol^a ; ; Carlos Sá ; nchez-Somolinos^b ; ; Valeria Grazú ; ^c ; Marí ; a Moros^c ; José ; Luis Serrano^c ; Jesú ; s Martí ; nez De la Fuente^c
• 关键词：Polyester ; Hyperbranched polymer ; Micropatterning ; Photopolymerization ; Cell adhesion ; Diazonium salt
• 刊名：Reactive and Functional Polymers
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：73
• 期：3
• 页码：499-507
• 全文大小：1111 K

文摘

Aliphatic hyperbranched polyesters of different generation, having different nucleophilic groups (such as hydroxyl or sulfonate) in the periphery, have been photocrosslinked by using a trifunctional low molecular weight diazonium salt. The photocrosslinking process, that does not require photoinitiator, allows to prepare polymeric materials that have shown not to cause cytotoxicity when used as substrate for cell growth. Furthermore, cell adhesion studies carried out in polymeric micropatterns generated in glass by direct laser writing, show that cells preferentially proliferate on the structure demonstrating cell affinity for the material.