MicroRNA changes through Müller glia dedifferentiation and early/late rod photoreceptor differentiation
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- 作者：H. Quintero ; A.I. Gó ; mez-Montalvo ; M. Lamas ; mlamas@cinvestav.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：DAPI ; 4 ; 6-diamidino-2-phenylindole ; GS ; Glutamine Synthetase ; MGDP ; Mü ; ller glia ; MG ; Mü ; ller glia-derived progenitor ; miRNAs ; MicroRNAs ; Nrl ; neural retina leucine zipper ; RA ; retinoic acid ; Rho ; rhodopsin ; RPCs ; retinal progenitor cells ; T ; taurine
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：316
- 期：Complete
- 页码：109-121
- 全文大小：2508 K
文摘
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We searched for candidate microRNAs (miRNAs) involved in mice rod photoreceptor and Müller glia (MG) specification.
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We compared miRNA expression microarrays from embryonic retinal progenitors (RPCs), CD73+ rods and MG primary cultures.
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We found divergence between CD73+ and MG-specific miRNA signatures and preferentially expressed miRNAs were validated.
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We revealed miRNA expression changes through MG dedifferentiation, early and late commitment to a rod-like phenotype.
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miR-124 and 29a are highlighted as potential targets to exploit the silent neuronal differentiation capacity of MG in mammals.