Experimental and in silico assessment of fate and effects of the antipsychotic drug quetiapine and its bio- and phototransformation products in aquatic environments
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- 作者：Manuel Herrmanna ; b ; manuel.herrmann@leuphana.de" class="auth_mail" title="E-mail the corresponding author ; Jakob Menza ; jakob.menz@leuphana.de" class="auth_mail" title="E-mail the corresponding author ; Matthias Gassmannc ; gassmann@uni-kassel.de" class="auth_mail" title="E-mail the corresponding author ; Oliver Olssona ; oliver.olsson@leuphana.de" class="auth_mail" title="E-mail the corresponding author ; Klaus Kü ; mmerera ; klaus.kuemmerer@leuphana.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Closed Bottle Test (CBT) ; High-resolution mass spectrometry ; Luminescent bacteria test ; Manometric Respirometry Test (MRT) ; Quetiapine carboxylic acid ; Umu-test
- 刊名：Environmental Pollution
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：218
- 期：Complete
- 页码：66-76
- 全文大小：1162 K
文摘
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One main biotransformation product (BTP) was formed from quetiapine (QUT).
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Six phototransformation products (PTPs) of QUT were identified for the first time.
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QUT was not readily biodegradable; photolytic mixture was not better biodegradable.
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Several different BTPs were formed from PTPs in the photolytic mixture.
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QUT showed cytotoxic activity in bacteria which was not reduced by photo-treatment.