Iron(III) phthalocyanine chloride-catalyzed oxidation-aromatization of α,β-unsaturated ketones with hydrazine hydrate: Synthesis of 3,5-disubstituted 1H-pyrazoles
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- 作者：Junlong Zhao ; zhaojunlong327@163.com" class="auth_mail" title="E-mail the corresponding author ; Jun Qiu ; Xiaofeng Gou ; Chengwen Hua ; Bang Chen
- 关键词：Iron(III) phthalocyanine chloride ; Aromatization ; Pyrazole ; Michael addition ; Recyclable catalyst ; Green chemistry
- 刊名：Chinese Journal of Catalysis
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：37
- 期：4
- 页码：571-578
- 全文大小：868 K
文摘
We have developed an iron(III) phthalocyanine chloride-catalyzed oxidation–aromatization of α,β-unsaturated ketones with hydrazine hydrate. Various 3,5-disubstituted 1H-pyrazoles were obtained in good to excellent yields. This method offers several advantages, including room-temperature conditions, short reaction time, high yields, simple work-up procedure, and use of air as an oxidant. The catalyst can be recovered and reused five times without loss of activity.