Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells
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- 作者：P.J. Ferrona ; pierre-jean.ferron@anses.fr" class="auth_mail" title="E-mail the corresponding author ; K. Hogeveena ; G. De Sousab ; R. Rahmanib ; E. Dubreilc ; V. Fessarda ; L. Le Hegarata
- 关键词：Phycotoxins ; Hepatocytes ; High content analysis ; CYP3A4 ; Cytotoxicity
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：136-146
- 全文大小：1871 K
文摘
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Liphophilic phycotoxins induced caspase-3 activation and γH2AX on human HepaRG cells.
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Inhibition of CYP3A4 increased toxic effect of toxins in HepaRG cells.
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Okadaic acid, dinophysistoxin-1 and 2 induced PXR activation in HepG2-PXR cell lines.
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Lipophilic phycotoxins did not induced cytochrome P450 activities in HepaRG cells.