Medication adherence and treatment success in the National Institute of Child Health and Human Development–Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

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• 作者：Peter G. McGovern ; S ; ra A. Carson ; Huiman X. Barnhart ; Evan R. Myers ; Richard S. Legro ; Michael P. Diamond ; Bruce R. Carr ; William D. Schlaff ; Christos Coutifaris ; Nicholas A. Cataldo ; Michael P. Steinkampf ; John E. Nestler ; Gabey Gosman ; Phyllis C. Leppert ; Linda C. Giudice ; For the NICHD-Reproduc
• 刊名：Fertility and Sterility
• 出版年：2008
• 出版时间：October 2008
• 年：2008
• 卷：90
• 期：4
• 页码：1283-1286
• 全文大小：102 K

文摘

We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.