Treatment for uterine fibroids: Searching for effective drug therapies

详细信息    查看全文

• 作者：Darlene K. Taylor¹ ; ² ; ^{dtaylor@NCCU.EDU} ; Phyllis C. Leppert²
• 刊名：Drug Discovery Today: Therapeutic Strategies
• 出版年：2012
• 出版时间：Spring, 2012
• 年：2012
• 卷：9
• 期：1
• 页码：e41-e49
• 全文大小：382 K

文摘

Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in African-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids are the leading indication for hysterectomy and their management averages $21 billion annually in the US. No long term minimally invasive therapies exist. Thus, promising drug therapies, their chemistry, pharmacology, and clinical efficacy, focusing first on innovative drug delivery approaches, are reviewed.