Interference of 1:1 and 2:1 layered phyllosilicates as excipients with ranitidine
详细信息 查看全文
- 作者：Zhaohui Lia ; b ; c ; li@uwp.edu" class="auth_mail" title="E-mail the corresponding author ; Nicole M. Fitzgeraldb ; Zachary Albertb ; Wei-Teh Jiangc
- 关键词：Cation exchange ; Drug uptake ; Excipient ; Kaolinite ; Sorption mechanism ; Talc
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：67-73
- 全文大小：1882 K
文摘
- •
Uptake of ranitidine (RT) on different clays governed by different mechanisms.
- •
Cation exchange was mainly responsible for RT uptake on kaolinite.
- •
Hydrogen bonding affected RT uptake on talc with multilayer sorption.
- •
The high RT adsorption suggested strong interference when the clay minerals were used as excipients.