Sex differences in the subjective effects of oral Δ⁹-THC in cannabis users

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• 作者：Jessica S. Fogel^b ; ¹ ; Thomas H. Kelly^a ; ^b ; ^c ; Philip M. Westgate^d ; Joshua A. Lile^a ; ^b ; ^c ; ^{jalile2@email.uky.edu}
• 关键词：Marijuana ; Cannabis ; Gender ; Drug-discrimination ; Self-report
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：44-51
• 全文大小：510 K
• 卷排序：152

文摘

Retrospective analysis of drug discrimination data was conducted to examine sex differences in acute effects of Δ9-THC. Subjects received a range of Δ9-THC doses (0, 5, 15 and a “high” dose of either 25 or 30 mg). Drug effects were assessed using drug discrimination, subjective effects, psychomotor performance, and physiological measures. Dose-dependent sex differences were found. Observed sex differences might contribute to the differential development of dependence in men and women.