Physiologically based pharmacokinetic toolkit to evaluate environmental exposures: Applications of the dioxin model to study real life exposures

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• 作者：Claude Emond^a ; ^{claude.emond@biosmc.com} ; Patricia Ruiz^b ; Moiz Mumtaz^b
• 关键词：Berkeley-Madonna ; Dioxin ; PBPK ; Risk assessment
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：315
• 期：Complete
• 页码：70-79
• 全文大小：759 K
• 卷排序：315

文摘

The best available dioxin PBPK model for interpreting human biomonitoring data is presented. The original PBPK model was recoded from acslX to the Berkeley Madonna (BM) platform. Comparisons were made of the accuracy of the recoded model with the original model. The model is a useful addition to the ATSDR's BM based PBPK toolkit that supports risk assessors. The application of the model to real-life exposure data sets is illustrated.