Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma

详细信息    查看全文

• 作者：Maria-Luisa Giudici¹ ; Jonathan H. Clarke¹ ; Robin F. Irvine ; ^{rfi20@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Phosphatidylinositol 5-phosphate ; Phosphatidylinositol 5-phosphate 4-kinase γ ; PI5P ; PI5P4K ; PI5P4Kγ
• 刊名：Advances in Biological Regulation
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：61
• 期：Complete
• 页码：47-50
• 全文大小：242 K

文摘

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are an important family of enzymes, whose physiological roles are being teased out by a variety of means. Phosphatidylinositol-5-phosphate 4-kinase γ (PI5P4Kγ) is especially intriguing as its in vitro activity is very low. Here we review what is known about this enzyme and discuss some recent advances towards an understanding of its physiology. Additionally, the effects of the ATP-competitive inhibitor I-OMe Tyrphostin AG-538 on all three mammalian PI5P4Ks was explored, including two PI5P4Kγ mutants with altered ATP- or PI5P-binding sites. The results suggest a strategy for targeting non-ATP binding sites on inositol lipid kinases.