Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons
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- 作者：Hyoung-Tai Kim1 ; Soung Jung Kim2 ; Young-In Sohn1 ; Sun-Sook Paik3 ; Romain Caplette4 ; 5 ; 6 ; Manuel Simonutti4 ; 5 ; 6 ; Kyeong Hwan Moon1 ; Eun Jung Lee1 ; Kwang Wook Min1 ; Mi Jeong Kim7 ; Dong-Gi Lee8 ; Antonio Simeone9 ; 10 ; Thomas Lamonerie11 ; Takahisa Furukawa12 ; 13 ; Jong-Soon Choi8 ; Hee-Seok Kweon7 ; Serge Picaud4 ; 5 ; 6 ; In-Beom Kim3 ; Minho Shong2 ; Jin Woo Kim1 ; jinwookim@kaist.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：3 November 2015
- 年：2015
- 卷：13
- 期：5
- 页码：990-1002
- 全文大小：5330 K
文摘
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Otx2 haplodeficiency results in retinal dystrophy in mice
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Otx2 proteins from photoreceptors are protective of retinal bipolar cells
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Exogenous Otx2 in bipolar cells is found into mitochondria and affects ATP synthesis
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Intraocular Otx2 injection restores retinal activity in Otx2−/+ mice