Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum
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- 作者：Ibolya Czegle ; Simona Piccirella ; Silvia Senesi ; Mikló ; s Csala ; Jó ; zsef Mandl ; Gá ; bor Bá ; nhegyi ; Rosella Fulceri and Angelo Benedetti
- 关键词：11β ; -Hydroxysteroid dehydrogenase type 1 ; Hexose-6-phosphate dehydrogenase ; Pyridine nucleotides ; Rat liver microsomes
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2006
- 出版时间：27 March 2006
- 年：2006
- 卷：248
- 期：1-2
- 页码：24-25
- 全文大小：80 K
文摘
11β-Hydroxysteroid dehydrogenase type 1 (11βHSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11βHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other.