Infants with low vaccine antibody responses have altered innate cytokine response

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• 作者：Naveen Surendran^a ; Ted Nicolosi^a ; Michael Pichichero^a ; ^b ; ^{Michael.Pichichero@rochesterregional.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Infant innate immunity ; Low vaccine response ; IRF7 ; IFN-α ; IL12p70 ; RANTES
• 刊名：Vaccine
• 出版年：2016
• 出版时间：11 November 2016
• 年：2016
• 卷：34
• 期：47
• 页码：5700-5703
• 全文大小：438 K

文摘

We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist – R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-α, IL-12p70 and IL-1β, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants.