Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model
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- 作者：David Verhoeven ; Qingfu Xu ; Michael E. Pichichero ; Michael.Pichichero@rochestergeneral.org" class="auth_mail ; kari.pedreira@rochestergeneral.org" class="auth_mail
- 关键词：Streptococcus pneumoniae ; Pneumolysin ; Pneumococcal histidine triad D protein ; Pneumococcal choline binding protein A ; Infant vaccination
- 刊名：Vaccine
- 出版年：30 May 2014
- 年：2014
- 卷：32
- 期：26
- 页码：3205-3210
- 全文大小：1342 K
文摘
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A trivalent vaccine, recombinant PcpA, PhtD and PlyD1, was effective in preventing pneumonia.
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The trivalent vaccine induced protection of both infant and adult mice.
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A reduction in Spn lung burden, in lung pathology, and secondary sepsis occurred.
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An infant mouse challenge model that mirrors immune responses to human infants was used.