Challenges in vaccination of neonates, infants and young children
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- 作者：Michael E. Pichichero ; Michael.Pichichero@rochestergeneral.org" class="auth_mail
- 关键词：Vaccination ; Neonate ; Infants ; Children ; B cells ; T cells ; Antigen presenting cells ; Dendritic cells ; immunologic memory ; pediatric vaccines ; Streptococcus pneumoniae ; Haemophilus influenzae ; B-cell receptor ; MHC II ; CD4 T-cells ; cytokines ; T-cell receptor ; Toll-like receptor
- 刊名：Vaccine
- 出版年：30 June 2014
- 年：2014
- 卷：32
- 期：31
- 页码：3886-3894
- 全文大小：2345 K
文摘
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Neonates and infants produce lower vaccine-specific IgG antibody than older children to vaccines.
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T-cell and B-cell memory in neonates and infants is inadequate for prolonged protection.
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Antigen presenting cells function inefficiently in processing vaccines in neonates and infants.
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Low vaccine responders among infants may have a prolonged neonatal-like immune profile.