From genes to therapeutic targets for psychiatric disorders ?what to expect?

详细信息    查看全文

• 作者：Pierandrea Muglia ;   ; ^{pierandrea.muglia@utoronto.ca}
• 刊名：Current Opinion in Pharmacology
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：11
• 期：5
• 页码：563-571
• 全文大小：243 K

文摘

Neuropsychiatric disorders as schizophrenia, autism and mood disorders represent one of the leading causes of disability. The cost of bringing a drug to the market is increasing and becoming more risky. Pharmaceutical investments in neuroscience are decreasing. At the same time we are facing an unprecedented rate of discovery in human genetics. Genes predisposing for common diseases including psychiatric disorders are being identified. The knowledge derived from the identification of genes relevant for psychiatric disorders holds the promise of providing truly innovative therapeutic interventions. The process of approving new psychiatric drugs, is however complex, lengthy and requires a well orchestrated and funded effort of multiple disciplines. In this article a brief overview of the key learning obtained from the conduction genome-wide association studies, thus far, is given in an attempt to provide a realistic view on the potential contribution of human genetics to drug discovery in psychiatry.