EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
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- 作者：Benjamin A. Olenchock1 ; 2 ; 3 ; 12 ; Javid Moslehi4 ; 12 ; Alan H. Baik5 ; Shawn M. Davidson3 ; Jeremy Williams6 ; William J. Gibson2 ; 6 ; Kerry A. Pierce7 ; Christine M. Miller8 ; 9 ; Eric A. Hanse10 ; Ameeta Kelekar10 ; Lucas B. Sullivan3 ; Amy J. Wagers8 ; 9 ; Clary B. Clish7 ; Matthew G. Vander Heiden3 ; 6 ; William G. Kaelin Jr.2 ; 6 ; 11 ; william_kaelin@dfci.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：25 February 2016
- 年：2016
- 卷：164
- 期：5
- 页码：884-895
- 全文大小：1802 K
文摘
Inhibition of EGLN1 locally or at a distance protects the heart against I/R injury
Remote ischemic protection after EGLN1 loss is mediated by a humoral factor
Diversion of the EGLN1 co-substrate αKG stimulates hepatic kynurenic acid production