Normal percentage of CD56bright natural killer cells in young patients with a history of repeated unexplained implantation failure after in vitro fertilization cycles

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• 作者：Maria G. Matteo ; Pantaleo Greco ; Piergiorgio Rosenberg ; Anna Mestice ; Domenico Baldini ; Teresa Falagario ; Vincenzo Martino ; Michele Santodirocco ; Francesca Massenzio ; Laura Castellana ; Giorgina Specchia ; Arcangelo Liso
• 刊名：Fertility and Sterility
• 出版年：2007
• 出版时间：October 2007
• 年：2007
• 卷：88
• 期：4
• 页码：990-993
• 全文大小：96 K

文摘

Changes in endometrial leukocyte subpopulations and most of all in the percentage of uterine natural-killer cells (uNK), during the menstrual cycles, may have a pivotal role in the implantation process. An increase of activated NK cells (CD56dim CD16+ CD69+) in the peripheral blood of patients with a reduced rate of embryo implantation in IVF treatment has been reported elsewhere, but we found, by using flow cytometry, normal endometrial lymphocyte subpopulations in young patients with a history of repeated unexplained implantation failure who were undergoing IVF cycles for idiopathic infertility.