Can Breast Cancer Biopsy Influence Sentinel Lymph Node Status?

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• 作者：Michela Giuliani¹ ; ^{micgiuli@yahoo.it" class="auth_mail" title="E-mail the corresponding author} ; Federica Patrolecco¹ ; Rossella Rella¹ ; Silvia Eleonora Di Giovanni¹ ; Amato Infante¹ ; Pierluigi Rinaldi¹ ; Maurizio Romani¹ ; Antonino Mulè ; ² ; Damiano Arciuolo² ; Paolo Belli¹ ; Lorenzo Bonomo¹
• 关键词：Cell displacement ; Dissemination ; Metastases ; Needle size ; Ultrasound
• 刊名：Clinical Breast Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：6
• 页码：e153-e157
• 全文大小：189 K

文摘

We evaluated whether the needle size could influence metastasis occurrence in the axillary sentinel lymph node (SLN) in ultrasound-guided core needle biopsy (US-CNB) of breast cancer (BC).

Materials and Methods

The data from all patients with breast lesions who had undergone US-CNB at our institution from January 2011 to January 2015 were retrospectively reviewed. A total of 377 BC cases were included using the following criteria: (1) percutaneous biopsy-proven invasive BC; and (2) SLN dissection with histopathologic examination. The patients were divided into 2 groups according to the needle size used: 14 gauge versus 16 or 18 gauge. SLN metastasis classification followed the 7th American Joint Committee on Cancer (2010) TNM pathologic staging factors: macrometastases, micrometastases, isolated tumor cells, or negative. Only macrometastases and micrometastases were considered positive, and the positive and negative rates were calculated for the overall population and for both needle size groups.

Results

Of the 377 BC cases, 268 US-CNB procedures were performed using a 14-gauge needle and 109 with a 16- or 18-gauge needle, respectively. The negative rate was significantly related statistically with the needle size, with a greater prevalence in the 14-gauge group on both extemporaneous analysis (P = .019) and definitive analysis (P = .002). The macrometastasis rate was 17% (63 of 377) for the 14-gauge and 3% (12 of 377) for the 16- and 18-gauge needles, respectively.

Conclusion

Our preliminary results have suggested that use of a large needle size in CNB does not influence SLN status; thus, preoperative breast biopsy can be considered a safe procedure in the diagnosis of malignant breast lesions.