Localization and role of inward rectifier K+ channels in Malpighian tubules of the yellow fever mosquito Aedes aegypti
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- 作者：Peter M. Piermarinia ; piermarini.1@osu.edu" class="auth_mail" title="E-mail the corresponding author ; Sonja M. Dunemanna ; Matthew F. Rouhiera ; Travis L. Calkinsa ; Rene Raphemotb ; c ; Jerod S. Dentonb ; c ; Rebecca M. Hined ; Klaus W. Beyenbachd
- 关键词：Potassium channels ; Pharmacology ; Small molecules ; Immunolocalization ; Electrophysiology ; Transepithelial fluid secretion
- 刊名：Insect Biochemistry and Molecular Biology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：67
- 期：Complete
- 页码：59-73
- 全文大小：3256 K
文摘
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AeKir1 and AeKir2B channels localize to the basolateral membranes of stellate and principal cells, respectively.
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AeKir3 channels localize to intracellular compartments of principal and stellate cells.
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AeKir1 channels contribute to 46% of the transepithelial K+ secretion in tubules challenged to secrete K+ at high rates.
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AeKir2B channels contribute to 20% of the transepithelial K+ secretion in tubules challenged to secrete K+ at high rates.
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The role of intracellular AeKir3 channels in transepithelial K+ secretion remains to be elucidated.