Does lacosamide aggravate Lennox–Gastaut syndrome? Report on three consecutive cases

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• 作者：Antonella Cuzzola ; Edoardo Ferlazzo ; Domenico Italiano ; Rocco Salvatore Calabrò ; Placido Bramanti ; Pierre Genton
• 关键词：Lennox– ; Gastaut syndrome ; Lacosamide
• 刊名：Epilepsy & Behavior
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：19
• 期：4
• 页码：650-651
• 全文大小：128 K

文摘

Lennox–Gastaut syndrome is an intractable epileptic encephalopathy, with most patients experiencing daily seizures despite therapy with multiple antiepileptic drugs. New treatments need to be tested to define their efficacy in this syndrome. Lacosamide is a new antiepileptic drug recently approved for the treatment of partial-onset seizures. We describe three patients with Lennox–Gastaut syndrome resistant to conventional antiepileptic drugs whose seizures were aggravated by lacosamide.