Spatial and temporal age-related spectral alterations in benign human breast tissue
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- 作者：Georgios Theophilou ; Simon W. Fogarty ; Jú ; lio Trevisan ; Rebecca J. Strong ; Kelly A. Heys ; Imran I. Patel ; Helen F. Stringfellow ; Pierre L. Martin-Hirsch ; Francis L. Martin ; f.martin@lancaster.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aetiology ; Biospectroscopy ; Breast cancer ; Multivariate analysis ; Synchrotron radiation-based Fourier-transform infrared (SR-FTIR) microspectroscopy ; Terminal ductal lobular unit
- 刊名：Journal of Molecular Structure
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：1106
- 期：Complete
- 页码：390-398
- 全文大小：2490 K
文摘
SR-FTIR microspectroscopy to examine benign breast tissue.
PCA-LDA of IR spectra shows inter-individual and age-related epithelial differences.
A subset of spectrally-distinct epithelial cells point to putative stem cells.
Spectral changes that may occur several years prior to onset of breast cancer.
Novel approach to shed insights into aetiology of breast cancer.