Inflammation, inflammasome and innate immunity plays a key role in stimulating metabolism, and vice versa.
HIV-1 infection is characterized by the activation of NLRP3-inflammasome and elevated inflammation that are fuelled by bacterial translocation and dysbiosis.
Inflammation and excessive metabolism during HIV-1 infection are not restored by ART.
Inflammation-related deregulation of metabolism in HIV-1-infected subjects results in a number of heath complications.