Anti-infective, cytotoxic and antioxidant activity of Ziziphus oxyphylla and Cedrela serrata

详细信息    查看全文

• 作者：Rizwan Ahmad¹ ; ^{rizvistar_36@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; ^{rareiyadh@uod.edu.sa" class="auth_mail" title="E-mail the corresponding author} ; Niyaz Ahmad² ; Atta Abbas Naqvi³ ; Paul Cos⁴ ; Louis Maes⁴ ; Sandra Apers⁵ ; Nina Hermans⁵ ; Luc Pieters⁵
• 关键词：Antifungal ; Antibacterial ; Antiprotozoal ; Cytotoxicity ; Antioxidant ; Ziziphus oxyphylla ; Cedrela serrata ; Rhamnaceae ; Meliaceae ; Pakistan
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：6
• 期：8
• 页码：671-676
• 全文大小：503 K

文摘

To search for the most active antimicrobial and antioxidant sub-fractions related to traditional use of Ziziphus oxyphylla (Z. oxyphylla) and Cedrela serrata (C. serrata) in Pakistan against infectious and liver diseases.

Methods

Factions of different polarity were tested in vitro for their antiprotozoal, antimalarial, antibacterial and antifungal activity against different pathogens. Cytotoxicity on MRC-5 cell lines (human lung fibroblasts) as well as, in vitro radical scavenging activity was evaluated using the 1, 1-diphenyl-2-picrylhydrazyl radical assay.

Results

The highest antiprotozoal activity was observed for the CHCl₃ fractions of Z. oxyphylla roots and leaves, and C. serrata bark. The CHCl₃ and EtOAc fractions of Z. oxyphylla roots, the CHCl₃ fraction of Z. oxyphylla leaves, the EtOAc and the residual MeOH: H₂O fraction of C. serrata bark showed antibacterial activity against Staphylococcus aureus. The same residual MeOH: H₂O fraction of C. serrata bark was active against Candida albicans. The highest antioxidant activity was observed for the more hydrophilic EtOAc fractions of Z. oxyphylla leaves, C. serrata bark and leaves, and the residual MeOH: H₂O fraction of C. serrata bark.

Conclusions

This study supports at least in part the traditional uses of these plants for antimicrobial purposes and against liver diseases.